Interval-Censored Data Analysis Assignment Help
Interval-censoring occurs in survival analysis when the time until an event of interest is not known precisely (and instead, only is known to fall into a particular interval). Such censoring commonly is produced when periodic assessments (usually clinical or laboratory examinations) are used to assess if the event has occurred.
My objectives were to raise awareness about interval-censoring including its existence, the potential ramifications of ignoring its existence, the different types of interval-censored data, and the analytical methods to analyze such data (including availability in standard statistical software).
Asynchronous interval-censored survival analysis was demonstrated by parametric evaluation of risk factors for the time to first detected shedding of Salmonella muenster (identified by repeated periodic fecal cultures) for a herd of dairy cows. These results were compared with those from survival analyses which ignored or approximated the interval-censoring. Ignoring or approximating the asynchronous interval-censoring in the survival analysis generally resulted in the risk factors’
In this class we will focus on the nonparametric maximum likelihood estimator (MLE) for various forms of censored data. Censored data arise in many contexts. In this chapter we consider a few examples and introduce some terminology. Note that all examples below are in the medical context (because I am most familiar with that). Other areas where censored data frequently arise are for example actuarial sciences (estimating the distribution of the lifetime/lifetime costs of people) and reliability theory (estimating the distribution of the failure time of machines)
Interval censoring is encountered in many practical situations when the event of interest cannot be observed and it is only known to have occurred within a time window. The theory for the analysis of interval-censored data has been developed over the past three decades and several reviews have been written. However, it is still a common practice in medical and reliability studies to simplify the interval censoring structure of the data into a more standard right censoring situation by, for instance, imputing the midpoint of the censoring interval. The availability of software for right censoring might well be the main reason for this simplifying practice. In contrast, several methods have been developed to deal with interval-censored data and the corresponding algorithms to make the procedures feasible are scattered across the statistical software or remain behind the personal computers of many researchers. The purpose of this tutorial is to present, in a pedagogical and unified manner, the methodology and the available software for analyzing interval-censored data. The paper covers frequentist non-parametric, parametric and semiparametric estimating approaches, non-parametric tests for comparing survival curves and a section on simulation of interval-censored data. The methods and the software are described using the data from a dental study.
The analysis of survival data is a major focus of statistics. Interval censored data reflect uncertainty as to the exact times the units failed within an interval. This type of data frequently comes from tests or situations where the objects of interest are not constantly monitored. Thus events are known only to have occurred between the two observation periods. Interval censoring has become increasingly common in the areas that produce failure time data. This paper explores the statistical analysis of interval-censored failure time data with applications. Three different data sets, namely Breast Cancer, Hemophilia, and AIDS data were used to illustrate the methods during this study. Both parametric and nonparametric methods of analysis are carried out in this study. Theory and methodology of fitted models for the interval-censored data are described. Fitting of parametric and non-parametric models to three real data sets are considered. Results derived from different methods are presented and also compared
Ignoring or approximating the asynchronous interval-censoring in the survival analysis generally resulted in the risk factors’ regression coefficients having the same signs and a decrease (often >50%) in their absolute size. All the standard errors from the three methods of approximating the interval-censoring were <40% of their interval-censored counterparts. The conclusions drawn from the asynchronous interval-censored analysis versus those from the approximations varied dramatically. (The general conclusion from the approximations was that none of the risk factors for this example warranted further consideration.) That ignoring or approximating the left- and interval-censored nature of the dependent variable resulted in biased results was consistent with the literature.
Interval-censored failure time data occur in many medical investigations as well as other studies such as demographical and sociological studies. They include the usual right-censored failure time data as a special case but provide much more complex structure and less relevant information than the right-censored data. This article reviews some basic concepts, issues and the corresponding statistical approaches related to the analysis of interval-censored data as well as recent advances. In particular, we discuss estimation of a survival function, comparison of several treatments and regression analysis as well as competing risks analysis and truncation in the presence of interval censoring. A well-known example of interval-censored data is described and analysed to illustrate some of the statistical procedures discussed.
In interval censoring, a random variable is known only to lie in an interval. In survival or failure-time data, this may arise, for instance, when a critical change has occurred sometime between a patient’s successive visits to a clinic. The survival distribution may be estimated by nonparametric maximum likelihood. Attention is given to the estimation of parameters in regression models and to the comparison of survival functions.
Interval regression is used to model outcomes that have interval censoring. In other words, you know the ordered category into which each observation falls, but you do not know the exact value of the observation. Interval regression is a generalization of censored regression. With interval censored data, you know only that the events occurred in some time interval. The Turnbull method is used to obtain nonparametric estimates of the survival function.
Example 1. We wish to model annual income using years of education and marital status. However, we do not have access to the precise values for income. Rather, we only have data on the income ranges: . Note that the extreme values of the categories on either end of the range are either left-censored or right-censored. The other categories are interval censored, that is, each interval is both left- and right-censored. Analyses of this type require a generalization of censored regression known as interval regression.